| Neurobiology: neurodegeneration and neuroregeneration
This group has extensive experience in the study of the molecular mechanisms involved in the regulation of neurogenesis in adult mammals and in the evolution of neurodegenerative diseases using genetically modified animal models. Likewise, they work on the identification of new biomolecules that play a key role in the development of these and other diseases such as brain tumors. These molecules are potential selective targets for the design of new drugs of therapeutic interest. They also perform clinical studies in patients with neurological and neuropsychiatric disorders using human brain stimulation, intracranial recordings and evaluation of cognitive deterioration through EEG-ERP.
Principal Investigator: Carmen Castro González (carmen.castro@uca.es)
Researchers:
Foreign collaborators:
| Brian J. Bacskai (Full Prof. Neurology) |
Harvard Medical School-Massachusetts General Hospital |
| Spires-Jones, Tara |
University of Edinburgh (UK) |
| Zsele, Francis S. |
Oxford University (UK) |
| Martínez-Barbera, Juan Pedro |
Children Hospital. University College of London, UK |
| Link: Research Proyects |
| Biological Chemistry: bioactive molecules and their molecular targets. Synthesis of biologically active molecules catalyzed by transition metals.
Chemical Biology is a field that has emerged from the interface between Chemistry and Biology and focuses on the study of the interactions of small molecules, including natural products, with proteins to identify their function in biological processes. This line of research includes metabolomic and genomic studies of phytopathogenic fungi, and the isolation, design and synthesis of PKC agonist molecules for the design of neurogenesis-promoting molecules. It also focuses on the search for new drugs and bioactive molecules, by isolation and biotransformation from terrestrial and marine microorganisms, and by transition metal-mediated synthetic methodologies.
Principal Investigators: Isidro González Collado (isidro.gonzalez@uca.es) and Rosario Hernández Galán (rosario.hernandez@uca.es)
Researchers:
Foreign collaborators:
| Dr. Hunter, A. Christy |
Leicester School of Pharmacy
(De Montfort University – UK) |
| Van Kan, Jan L. |
Phytopathology department, Wageningen University, Wageningen, Holand |
|
| Biocommunicators as a source of bioactive products. Synthetic methodologies, mechanisms, and reaction kinetics
One of the main aspects developed in this research line focuses on the fields of Allelopathy and Venomics. Natural products, isolated or synthetic, are used to understand the molecular processes that regulate interaction and/or communication in higher plants, microorganisms, and venomous animals. Additionally, methodologies for functionalizing C-H bonds at activated positions using catalysts, both metallic and non-metallic, are developed using green chemistry techniques. Microwave radiation and ultrasound are examples of these techniques. Another aspect included in this research line is the investigation of the kinetics and reaction mechanisms with biological relevance. Those involving mono and polynuclear metal centers as models of metalloenzymes capable of functionalizing organic molecules are of special interest.
Principal Investigator: Francisco Antonio Macías Domínguez (famacias@uca.es)
Researchers:
| Castillo González, Carmen Ester |
esther.castillo@uca.es |
| Chinchilla Salcedo, Nuria |
nuria.chinchilla@uca.es |
| Fernández-Trujillo Rey, Mª Jesús |
mariajesus.fernandez@uca.es |
| García Algarra, Andrés |
andres.algarra@uca.es |
| García Basallote, Manuel |
manuel.basallote@uca.es |
| García Galindo, Juan Carlos |
juancarlos.galindo@uca.es |
| González Molinillo, Jose María |
chema.gonzalez@uca.es |
| Guerra Martínez, Francisco Miguel |
francisco.guerra@uca.es |
| Macías Domínguez, Francisco Antonio |
famacias@uca.es |
| Moreno Dorado, Francisco Javier |
javi.moreno@uca.es |
| Simonet Morales, Ana María |
ana.simonet@uca.es |
Foreign collaborators:
| Duke, Steve O. |
NPURU. Oxford, Mississippi (USA) |
| Lanzotti, Virginia |
Università degli Studi di Napoli Federico II (Nápoles, Italia) |
| Bucar, Franz |
Karl-Franzens-Universität Graz, Austria |
|
| Biomedicine of inflammation and Biotechnology applied to new therapies
Development of anti-tumor, anti-infectious or pro-tolerogenic cell therapies using immune system cells modified by gene therapy and labeled using nanoparticles. Analysis of intracellular signals involved in lymphocyte activation and homeostasis and their possible implications in autoimmune diseases. Study of cell combinations for use in cell therapy in cardiovascular diseases and analysis of associated protein biomarkers. Study of phosphate polymers (polyphosphates) and their molecular interactions in human pathologies.
Principal Investigator: Francisco José García Cozar (curro.garcia@uca.es)
Researchers:
Foreign collaborators:
| Miazek, Arkadiusz |
Polish Academy of Sciences |
| Feskes, Stephan |
New York University |
|
|
